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- Title
Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene.
- Authors
Ichimura, Yohei; Asano, Yoshihide; Hatano, Masaru; Tamaki, Zenshiro; Takekoshi, Tomonori; Kogure, Asako; Tomita, Manabu; Kawashima, Tomohiko; Miyazaki, Miki; Taniguchi, Takashi; Takahashi, Takehiro; Mitsui, Hiroshi; Sugaya, Makoto; Yao, Atsushi; Kinugawa, Koichiro; Sato, Shinichi
- Abstract
Systemic sclerosis (SSc) is characterized by vascular injuries, and bosentan has recently been proved to be efficacious for the prevention of new digital ulcers in SSc. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc.
- Publication
Modern Rheumatology, 2011, Vol 21, Issue 5, p548
- ISSN
1439-7595
- Publication type
Academic Journal
- DOI
10.3109/s10165-011-0436-5