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- Title
Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats.
- Authors
Agholme, Fredrik; Isaksson, Hanna; Li, Xiaodong; Ke, Hua Zhu; Aspenberg, Per
- Abstract
Sclerostin is produced by osteocytes and is an inhibitor of bone formation. Thus, inhibition of sclerostin by a monoclonal antibody increases bone formation and improves fracture repair. Sclerostin expression is upregulated in unloaded bone and is downregulated by loading. We wanted to determine whether an anti-sclerostin antibody would stimulate metaphyseal healing in unloaded bone in a rat model.
- Publication
Acta orthopaedica, 2011, Vol 82, Issue 5, p628
- ISSN
1745-3682
- Publication type
Journal Article
- DOI
10.3109/17453674.2011.625539