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- Title
Accelerated fracture healing in mice lacking the 5-lipoxygenase gene.
- Authors
Manigrasso, Michaele B; O'Connor, J Patrick
- Abstract
Cyclooxygenase-2 (COX-2) promotes inflammation by synthesizing pro-inflammatory prostaglandins from arachidonic acid. Inflammation is an early response to bone fracture, and ablation of COX-2 activity impairs fracture healing. Arachidonic acid is also converted into leukotrienes by 5-lipoxygenase (5-LO). We hypothesized that 5-LO is a negative regulator of fracture healing and that in the absence of COX-2, excess leukotrienes synthesized by 5-LO will impair fracture healing.
- Publication
Acta orthopaedica, 2010, Vol 81, Issue 6, p748
- ISSN
1745-3682
- Publication type
Journal Article
- DOI
10.3109/17453674.2010.533931