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- Title
Comparison of oral and transdermal administration of rasagiline mesylate on human melanoma tumor growth in vivo.
- Authors
Meier-Davis, Susan R; Dines, Kevin; Arjmand, Fatima M; Hamlin, Richard; Huang, Betsy; Wen, Jainye; Christianson, Chad; Shudo, Jutaro; Nagata, Tetsuto
- Abstract
Transdermal patch administration results in a locally high concentration of drug that induce local toxicity, including tumorogenicity. As a worst-case scenario for consequences of repeated application on neoplastic growth, the melanin-binding drug, rasagiline, was used in a transdermal formulation applied directly to a human-derived melanoma to determine the effects on tumor growth.
- Publication
Cutaneous and ocular toxicology, 2012, Vol 31, Issue 4, p312
- ISSN
1556-9535
- Publication type
Journal Article
- DOI
10.3109/15569527.2012.676119