We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Irritant contact dermatitis: effect of age.
- Authors
Zhai, Hongbo; Meier-Davis, Susan R; Cayme, Brenda; Shudo, Jutaro; Maibach, Howard
- Abstract
Knowledge on age-relationship to irritant contact dermatitis (ICD) remains of interest. We searched for articles and textbooks on age-relationship to ICD and evaluated relevant data. Irritant response may be enhanced in children and decline with increasing age. In general, older skin reacts more slowly and with less intensity to irritants when compared with young skin. Such age-related changes may depend: (i) on differences in percutaneous penetration in old and young skin, and/or on (ii) differences in the microcirculatory efficiency, which serves as the route by which inflammatory cells make their way to the site of inflammation. Additionally, stratum corneum turnover time increases with age which means that an irritant remains longer on the skin; a compromised cutaneous blood vessel network with ageing may lead to a decreased inflammatory response, decreased absorption and decreased clearance. In conclusion, age-related differences of ICD are present despite some conflicting data. Investigations elucidating this interesting subject may benefit in prevention and intervention strategies.
- Publication
Cutaneous and ocular toxicology, 2012, Vol 31, Issue 2, p138
- ISSN
1556-9535
- Publication type
Journal Article
- DOI
10.3109/15569527.2011.618472