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- Title
Comparison and evaluation of urinary biomarkers for occupational exposure to spray adhesives containing 1-bromopropane.
- Authors
Mathias, Patricia I; Cheever, Kenneth L; Hanley, Kevin W; Marlow, Katherine L; Johnson, Belinda C; B'hymer, Clayton
- Abstract
Three metabolites of 1-bromopropane (1-BP) were measured in urine samples collected from 30 workers exposed to 1-BP at two facilities making furniture seat cushions and evaluated for use as biomarkers of exposure. The mercapturic acid metabolite, N-acetyl-S-(n-propyl)-l-cysteine (AcPrCys), 3-bromopropionic acid (3-BPA), and bromide ion levels (Br(-)) were quantitated for this evaluation. The high exposure group consisted of 13 workers employed as adhesive sprayers who assembled foam cushions using 1-BP containing spray adhesives and the low exposure group consisted of 17 non-sprayers, who worked in various jobs without spraying adhesives. All workers' urine voids were collected over the same 48 h period at work, and at home before bedtime, and upon awakening. Urinary AcPrCys and Br(-) levels were elevated in the sprayers compared to that of non-sprayers. Following HPLC-MS/MS analysis of mercapturic acid metabolite levels, 50 urine samples having the highest levels of AcPrCys were analyzed for 3-BPA. No 3-BPA was detected in any of the samples. The data collected from this study demonstrate that AcPrCys and Br(-) are effective biomarkers of 1-BP exposure, but 3-BPA is not.
- Publication
Toxicology mechanisms and methods, 2012, Vol 22, Issue 7, p526
- ISSN
1537-6524
- Publication type
Journal Article
- DOI
10.3109/15376516.2012.686536