We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation.
- Authors
Romero, Roberto; Kusanovic, Juan Pedro; Gotsch, Francesca; Erez, Offer; Vaisbuch, Edi; Mazaki-Tovi, Shali; Moser, Allan; Tam, Sunny; Leszyk, John; Master, Stephen R; Juhasz, Peter; Pacora, Percy; Ogge, Giovanna; Gomez, Ricardo; Yoon, Bo H; Yeo, Lami; Hassan, Sonia S; Rogers, Wade T
- Abstract
Examination of the amniotic fluid (AF) proteome has been previously attempted to identify useful biomarkers in predicting the outcome of preterm labor (PTL). Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) labeling allows direct ratiometric comparison of relative abundance of identified protein species among multiplexed samples. The purpose of this study was to apply, for the first time, the combination of iTRAQ and tandem mass spectrometry to identify proteins differentially regulated in AF samples of women with spontaneous PTL and intact membranes with and without intra-amniotic infection/inflammation (IAI).
- Publication
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2010, Vol 23, Issue 4, p261
- ISSN
1476-4954
- Publication type
Journal Article
- DOI
10.3109/14767050903067386