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- Title
Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition.
- Authors
Yeghiazarians, Yerem; Gaur, Meenakshi; Zhang, Yan; Sievers, Richard E; Ritner, Carissa; Prasad, Megha; Boyle, Andrew; Bernstein, Harold S
- Abstract
We have shown previously that inhibition of the p38 mitogen-activated protein kinase (p38MAPK) directs the differentiation of human embryonic stem cell (hESC)-derived cardiomyocytes (hCM). We investigated the therapeutic benefits of intramyocardial injection of hCM differentiated from hESC by p38MAPK inhibition using closed-chest ultrasound-guided injection at a clinically relevant time post-myocardial infarction (MI) in a mouse model.
- Publication
Cytotherapy, 2012, Vol 14, Issue 2, p223
- ISSN
1477-2566
- Publication type
Journal Article
- DOI
10.3109/14653249.2011.623690