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- Title
Unrestricted somatic stem cells: interaction with CD34+ cells in vitro and in vivo, expression of homing genes and exclusion of tumorigenic potential.
- Authors
Jeltsch, Kathrin Sonja; Radke, Teja Falk; Laufs, Stephanie; Giordano, Frank Anton; Allgayer, Heike; Wenz, Frederik; Zeller, Walter Jens; Kögler, Gesine; Fruehauf, Stefan; Maier, Patrick
- Abstract
Transplantation of allogeneic hematopoietic stem cells (HSC) within the framework of hematologic oncology or inherited diseases may be associated with complications such as engraftment failure and long-term pancytopenia. HSC engraftment can be improved, for example by co-transplantation with mesenchymal stem cells (MSC). Recently, a new multipotent MSC line from umbilical cord blood, unrestricted somatic stem cells (USSC), has been described. It was demonstrated that USSC significantly support proliferation of HSC in an in vitro feeder layer assay.
- Publication
Cytotherapy, 2011, Vol 13, Issue 3, p357
- ISSN
1477-2566
- Publication type
Journal Article
- DOI
10.3109/14653249.2010.523076