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- Title
Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.
- Authors
Gaur, Meenakshi; Ritner, Carissa; Sievers, Rich; Pedersen, Anissa; Prasad, Megha; Bernstein, Harold S; Yeghiazarians, Yerem
- Abstract
Heart failure therapy with human embryonic stem cell (hESC)-derived cardiomyocytes (hCM) has been limited by the low rate of spontaneous hCM differentiation. As others have shown that p38 mitogen-activated protein kinase (p38MAPK) directs neurogenesis from mouse embryonic stem cells, we investigated whether the p38MAPK inhibitor, SB203580, might influence hCM differentiation.
- Publication
Cytotherapy, 2010, Vol 12, Issue 6, p807
- ISSN
1477-2566
- Publication type
Journal Article
- DOI
10.3109/14653249.2010.491821