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- Title
Dendritic cell vaccination in an allogeneic stem cell recipient receiving a transplant from a human cytomegalovirus (HCMV)-seronegative donor: induction of a HCMV-specific T(helper) cell response.
- Authors
Feuchtinger, Tobias; Opherk, Kathrin; Bicanic, Oliver; Schumm, Michael; Grigoleit, Götz Ulrich; Hamprecht, Klaus; Jahn, Gerhard; Handgretinger, Rupert; Lang, Peter
- Abstract
In the absence of a protective immune response, human cytomegalovirus (HCMV) infection remains a life-threatening complication after allogeneic stem cell transplantation (SCT), especially in recipients of grafts from HCMV-seronegative donors. After allogeneic SCT from a seronegative donor, prolonged and severe immune deficiency often leads to infectious complications. Vaccination with antigen-loaded dendritic cells (DC) has been shown to be a potent approach for the induction of antigen-specific cytotoxic T-cell responses in vivo. For protection from subsequent HCMV reactivation, a sustained immune response is necessary, including antigen-specific CD4(+) T cells.
- Publication
Cytotherapy, 2010, Vol 12, Issue 7, p945
- ISSN
1477-2566
- Publication type
Journal Article
- DOI
10.3109/14653241003587645