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- Title
Targeted antagonism of CXCR4 mobilizes progenitor cells under investigation for cardiovascular disease.
- Authors
Blum, Arnon; Childs, Richard W; Smith, Aleah; Patibandla, Sushmitha; Zalos, Gloria; Samsel, Leigh; McCoy, J Philip; Calandra, Gary; Csako, Gyorgy; Cannon, Richard O, 3rd
- Abstract
Bone marrow (BM)-derived cells may repair cardiovascular injury but populations of interest circulate in small numbers. Cytokines such as granulocyte-colony-stimulating factor mobilize cells under investigation for this purpose, including CD133+ but require injections over multiple days and may promote inflammation. The purpose of this study was to evaluate the effects of a novel CXCR4 inhibitor (plerixafor), previously shown to mobilize CD34+ stem cells, on CD133+ mobilization and markers of inflammation.
- Publication
Cytotherapy, 2009, Vol 11, Issue 8, p1016
- ISSN
1477-2566
- Publication type
Journal Article
- DOI
10.3109/14653240903131640