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- Title
LAPTM4B gene polymorphism and endometrial carcinoma risk and prognosis.
- Authors
Meng, Fanling; Li, Huiyan; Zhou, Rouli; Luo, Chang; Hu, Yuanlong; Lou, Ge
- Abstract
A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) plays several crucial roles in carcinogenesis. In this case-control study, we investigated the relationship between LAPTM4B gene polymorphism and susceptibility to endometrial carcinoma (EC). In an adjusted multivariate logistic regression analyses, subjects with the LAPTM4B*1/2 and *2/2 genotypes respectively exhibited 1.572-fold (95% confidence interval (CI) = 1.041-2.375) and 2.335-fold (95% CI = 1.365-3.995) increases in the risk of developing EC relative to those carrying LAPTM4B*1/1. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both p < 0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both p < 0.001). These results suggest that LAPTM4B polymorphisms might play an important role in the aetiology of EC.
- Publication
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2013, Vol 18, Issue 2, p136
- ISSN
1366-5804
- Publication type
Journal Article
- DOI
10.3109/1354750X.2012.752526