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- Title
The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.
- Authors
Kang-Sickel, Juei-Chuan C; Butler, Mary Ann; Frame, Lynn; Serdar, Berrin; Chao, Yi-Chun E; Egeghy, Peter; Rappaport, Stephen M; Toennis, Christine A; Li, Wang; Borisova, Tatyana; French, John E; Nylander-French, Leena A
- Abstract
We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
- Publication
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2011, Vol 16, Issue 7, p590
- ISSN
1366-5804
- Publication type
Journal Article
- DOI
10.3109/1354750X.2011.611598