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- Title
The influence of beta-arrestin2 on cannabinoid CB1 receptor coupling to G-proteins and subcellular localization and relative levels of beta-arrestin1 and 2 in mouse brain.
- Authors
Breivogel, Christopher S; Puri, Vanita; Lambert, Jonathan M; Hill, Deryck K; Huffman, John W; Razdan, Raj K
- Abstract
Beta-arrestins are known to couple to some G-protein-coupled receptors (GPCRs) to regulate receptor internalization, G-protein coupling and signal transduction, but have not been investigated for most receptors, and for very few receptors in vivo. Previous studies have shown that beta-arrestin2 deletion enhances the efficacy of specific cannabinoid agonists.
- Publication
Journal of receptor and signal transduction research, 2013, Vol 33, Issue 6, p367
- ISSN
1532-4281
- Publication type
Journal Article
- DOI
10.3109/10799893.2013.838787