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Title
Colon-targeted celecoxib-loaded Eudragit® S100-coated poly-ε-caprolactone microparticles: preparation, characterization and in vivo evaluation in rats.
Authors
Ghorab, Dalia M; Amin, Maha Mohamed; Khowessah, Omneya M; Tadros, Mina Ibrahim
Abstract
Celecoxib suffers from low and variable bioavailability following oral administration of solutions or capsules. Recent studies proved that chemoprevention of colorectal cancer is possible with celecoxib.