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- Title
Efficacy and tolerability of a single-pill combination of amlodipine/valsartan in Asian hypertensive patients not adequately controlled with valsartan monotherapy.
- Authors
Huang, Jun; Sun, Ning-Ling; Hao, Yu-Ming; Zhu, Jun-Ren; Tu, Yingmei; Curt, Valentin; Zhang, Ying; Trial Investigators
- Abstract
This randomized, double-blind study evaluated efficacy of a single-pill combination of amlodipine/valsartan (Aml/Val) in Asian patients with hypertension not responding to Val 80 mg. Patients with mean sitting diastolic blood pressure (DBP) ≥90-≤110 mmHg were randomized to Aml/Val 5/80, Val 80, or Val 160 mg for 8 weeks. At week-8 endpoint, significantly greater reductions in BP were seen with Aml/Val 5/80 mg than valsartan monotherapies (p < 0.0001). The BP control was greater with Aml/Val 5/80 (70.5%) than Val (44.1-58.6%) monotherapies. The combination was well tolerated. In conclusion, single-pill combination with Aml/Val provided significant additional BP reduction and control in hypertensive patients not responding to Val 80 mg.
- Publication
Clinical and experimental hypertension (New York, N.Y. : 1993), 2011, Vol 33, Issue 3, p179
- ISSN
1525-6006
- Publication type
Journal Article
- DOI
10.3109/10641963.2010.531849