We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of effects of low dose of spironolactone and a thiazide diuretic in patients with hypertension treated with an angiotensin-converting enzyme inhibitor or an angiotensin type 1 receptor blocker.
- Authors
Yutaka, Miyashita; Mifune, Mizuo; Kubota, Eiji; Itoh, Hiroshi; Saito, Ikuo
- Abstract
This study was performed to investigate the additional anti-hypertensive effects and safety of low-dose thiazide diuretic, trichlormethiazide (TCTZ), and a mineralocorticoid receptor blocker, spironolactone (SPI), as add-on therapy in 64 patients whose blood pressure (BP) at office were over 140/90 mmHg, while receiving anti-hypertensive medication including an angiotensin-converting enzyme inhibitor or angiotensin II type I receptor antagonist. After 6 months, we observed a decrease of office and home BP. Moreover, urinary albumin excretion (UAE) was reduced in SPI-treated group, but not in the TCTZ-treated group. No significant change in serum potassium, lipids, glucose, or uric acid was observed. In conclusion, low-dose thiazide diuretic or SPI provided a significant additional anti-hypertensive effect in patients in whom hypertension was not controlled by medication, and SPI-reduced UAE.
- Publication
Clinical and experimental hypertension (New York, N.Y. : 1993), 2009, Vol 31, Issue 8, p648
- ISSN
1525-6006
- Publication type
Journal Article
- DOI
10.3109/10641960903407017