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- Title
Combination of skin-directed therapy and oral etoposide for smoldering adult T-cell leukemia/lymphoma with skin involvement.
- Authors
Sawada, Yu; Shimauchi, Takatoshi; Yamaguchi, Takashi; Okura, Risa; Hama-Yamamoto, Kayo; Fueki-Yoshioka, Haruna; Ohmori, Shun; Yamada, Shigenori; Yoshizawa, Mayuko; Hiromasa, Kana; Tajiri, Makiko; Kabashima-Kubo, Rieko; Yoshioka, Manabu; Sugita, Kazunari; Yoshiki, Ryutaro; Hino, Ryosuke; Kobayashi, Miwa; Izu, Kunio; Nakamura, Motonobu; Tokura, Yoshiki
- Abstract
Approximately 50% of patients with adult T-cell leukemia/lymphoma (ATLL) have skin involvement, and the smoldering, skin lesion-bearing cases are often treated with various skin-directed therapies, such as phototherapy and radiation therapy. Daily oral administration of etoposide plus prednisolone (EP) is also used for smoldering-type ATLL. However, it remains unclear whether these therapies improve patients' survival. We retrospectively analyzed the prognosis of patients with smoldering, skin lesion-bearing ATLL (n = 62), who were treated, as first therapy, with one skin-directed therapy (n = 29), oral EP alone (n = 14) or a combination of skin-directed therapy and oral EP (n = 19). Multivariate analysis revealed that the hazard ratios (HRs) for the overall survival (OS) and progression-free survival (PFS) with the combination therapy were significantly lower than those with the skin-directed therapy (HR 0.1, p = 0.001; HR 0.2, p = 0.002, respectively). These results suggest that the combination of skin-directed therapy and oral EP improves the clinical outcome of patients with smoldering, skin lesion-bearing ATLL.
- Publication
Leukemia & lymphoma, 2013, Vol 54, Issue 3, p520
- ISSN
1029-2403
- Publication type
Journal Article
- DOI
10.3109/10428194.2012.715351