We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemokine polymorphisms and lymphoma: a pooled analysis.
- Authors
Bracci, Paige M; Skibola, Christine F; Conde, Lucia; Halperin, Eran; Lightfoot, Tracy; Smith, Alex; Paynter, Randi A; Skibola, Danica R; Agana, Luz; Roman, Eve; Kane, Eleanor; Wiencke, John K
- Abstract
Polymorphisms in chemokine genes have been associated with human immunodeficiency virus (HIV)-related non-Hodgkin lymphoma (NHL) but are understudied in non-HIV-related NHL. Associations of NHL and NHL subtypes with polymorphisms and haplotypes in CCR5, CCR2, CCL5, CXCL12, and CX(3)CR(1) were explored in a pooled analysis of three case-control studies (San Francisco Bay Area, California; United Kingdom; total: cases N = 1610, controls N = 1992). Adjusted unconditional logistic regression was used to estimate relative risks among HIV-negative non-Hispanic Caucasians. The CCR5 Delta32 deletion reduced the risk of NHL (odds ratio = 0.56, 95% confidence interval = 0.38-0.83) in men but not women with similar effects observed for diffuse large-cell and follicular lymphoma (FL). NHL risk also was reduced in men with the CCR2/CCR5 haplotype characterized by the CCR5 Delta32 deletion. The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings.
- Publication
Leukemia & lymphoma, 2010, Vol 51, Issue 3, p497
- ISSN
1029-2403
- Publication type
Journal Article
- DOI
10.3109/10428190903518337