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- Title
Telomere shortening and ionizing radiation: a possible role in vascular dysfunction?
- Authors
Sabatino, Laura; Picano, Eugenio; Andreassi, Maria Grazia
- Abstract
In recent years, growing epidemiological evidence has linked ionizing radiation exposure to cardiovascular atherosclerotic disease. However, there are still major gaps in the knowledge of the molecular mechanisms of radiation-induced vascular disease, especially for low-dose levels. Telomeres, repetitive DNA sequences of (TTAGGG)(n) located at the ends of eukaryotic chromosomes, play a role in regulating vascular aging, and shorter leukocyte telomere length has been demonstrated to predict cardiovascular disease and mortality. There is also evidence supporting the crucial role of telomeres in the formation of chromosome and chromatid aberrations induced by ionizing radiation.
- Publication
International journal of radiation biology, 2012, Vol 88, Issue 11, p830
- ISSN
1362-3095
- Publication type
Journal Article
- DOI
10.3109/09553002.2012.709307