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- Title
MyD88 provides a protective role in long-term radiation-induced lung injury.
- Authors
Brickey, Willie J; Neuringer, Isabel P; Walton, William; Hua, Xiaoyang; Wang, Ellis Y; Jha, Sushmita; Sempowski, Gregory D; Yang, Xuebin; Kirby, Suzanne L; Tilley, Stephen L; Ting, Jenny P-Y
- Abstract
The role of innate immune regulators is investigated in injury sustained from irradiation as in the clinic for cancer treatment or from a nuclear incident. The protective benefits of flagellin signaling through Toll-like receptors (TLR) in an irradiation setting warrant study of a key intracellular adaptor of TLR signaling, namely Myeloid differentiation primary response factor 88 (MyD88). The role of MyD88 in regulating innate immunity and Nuclear factor kappa-B (NF-κB)-activated responses targets this critical factor for influencing injury and recovery as well as maintaining immune homeostasis.
- Publication
International journal of radiation biology, 2012, Vol 88, Issue 4, p335
- ISSN
1362-3095
- Publication type
Journal Article
- DOI
10.3109/09553002.2012.652723