We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage.
- Authors
Lobachevsky, Pavel N; Vasireddy, Raja S; Broadhurst, Sam; Sprung, Carl N; Karagiannis, Tom C; Smith, Andrea J; Radford, Ian R; McKay, Michael J; Martin, Roger F
- Abstract
The therapeutic ratio for ionising radiation treatment of tumour is a trade-off between normal tissue side-effects and tumour control. Application of a radioprotector to normal tissue can reduce side-effects. Here we study the effects of a new radioprotector on the cellular response to radiation. Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA. To substantiate this hypothesis, we studied protection by methylproamine at both clonogenic survival and radiation-induced DNA damage, assessed by γH2AX (histone 2AX phosphorylation at serine 139) focus formation endpoints.
- Publication
International journal of radiation biology, 2011, Vol 87, Issue 3, p274
- ISSN
1362-3095
- Publication type
Journal Article
- DOI
10.3109/09553002.2011.530333