We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity.
- Authors
Chaudhry, M Ahmad; Kreger, Bridget; Omaruddin, Romaica A
- Abstract
The molecular basis of gene regulation in cells exposed to ionising radiation is not fully understood. Gene regulation occurs at the transcriptional and post-transcriptional levels. Recent studies have suggested that micro-RNA (miRNA) plays a significant role at the post-transcriptional gene regulation. miRNA are a recently identified class of RNA molecules 18-24 nucleotides in length that have been shown to negatively regulate the stability or translation of target messenger RNA. We hypothesised that ionising radiation induced stress response is controlled in part by miRNA and that a difference in tumour protein 53 (p53) status corresponds with altered expression in miRNA responses to ionising radiation.
- Publication
International journal of radiation biology, 2010, Vol 86, Issue 7, p569
- ISSN
1362-3095
- Publication type
Journal Article
- DOI
10.3109/09553001003734568