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- Title
Development of a method for assessing non-targeted radiation damage in an artificial 3D human skin model.
- Authors
Schettino, Giuseppe; Johnson, Gary W; Marino, Steve A; Brenner, David J
- Abstract
Despite the increasing concern about the effect of doses below 0.5 Gy and non-targeted exposures of ionising radiation on living organisms, the majority of radiobiological studies are conducted using in vitro cell lines. In order to be able to extrapolate the in vitro results to in vivo models with confidence, it would be of great benefit to develop a reproducible tissue system suitable for critical radiobiological assays. This manuscript describes the development of a reliable protocol to harvest cells from tissue samples and investigate the radiation damage induced on a single cell basis.
- Publication
International journal of radiation biology, 2010, Vol 86, Issue 7, p593
- ISSN
1362-3095
- Publication type
Journal Article
- DOI
10.3109/09553001003734535