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- Title
CalDAG-GEFI and platelet activation.
- Authors
Stefanini, Lucia; Bergmeier, Wolfgang
- Abstract
Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. Here, we review recent findings, which (a) identified CalDAG-GEFI (RasGRP2) at the nexus of the rapid Ca(2+)-dependent platelet activation, (b) demonstrated a complex synergy between signaling provided by CalDAG-GEFI, protein kinase C and the Gi-coupled receptor for ADP, P2Y12, and (c) suggested CalDAG-GEFI as a novel target for anti-platelet therapy.
- Publication
Platelets, 2010, Vol 21, Issue 4, p239
- ISSN
1369-1635
- Publication type
Journal Article
- DOI
10.3109/09537101003639931