We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antigen-specific versus antigen-nonspecific immunotherapeutic approaches for human melanoma: the need for integration for optimal efficacy?
- Authors
Tietze, Julia K; Sckisel, Gail D; Hsiao, Hui-Hua; Murphy, William J
- Abstract
Due to its immunogenecity and evidence of immune responses resulting in tumor regression, metastatic melanoma has been the target for numerous immunotherapeutic approaches. Unfortunately, based on the clinical outcomes, even the successful induction of tumor-specific responses does not correlate with efficacy. Immunotherapies can be divided into antigen-specific approaches, which seek to induce T cells specific to one or several known tumor associated antigens (TAA), or with antigen-nonspecific approaches, which generally activate T cells to become nonspecifically lytic effectors. Here the authors critically review the different immunotherapeutic approaches in melanoma.
- Publication
International reviews of immunology, 2011, Vol 30, Issue 5-6, p238
- ISSN
1563-5244
- Publication type
Journal Article
- DOI
10.3109/08830185.2011.598977