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- Title
Recombinant modified vaccinia virus ankara (MVA) expressing wild-type human p53 induces specific antitumor CTL expansion.
- Authors
Song, Guang-Yun; Srivastava, Tumul; Ishizaki, Hidenobu; Lacey, Simon F; Diamond, Don J; Ellenhorn, Joshua D I
- Abstract
The p53 gene product is an attractive target for tumor immunotherapy. The present study aims to understand the potential of MVAp53 vaccine to induce expansion of p53-specific cytotoxic T lymphocyte ex vivo in cancer patients. The result indicated that 14 of 23 cancer patients demonstrated p53-specific IFN-γ production, degranulation, cell proliferation, and lysis of p53 overexpressed human tumor cell lines. These experiments show that MVAp53 stimulation has the potential to induce the expansion of p53-specific cytotoxic T lymphocyte from the memory T cell repertoire. The data suggest that MVAp53 vaccine is an ideal candidate for cancer immunotherapy.
- Publication
Cancer investigation, 2011, Vol 29, Issue 8, p501
- ISSN
1532-4192
- Publication type
Journal Article
- DOI
10.3109/07357907.2011.606248