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- Title
Epigenetic alteration of the Wnt inhibitory factor-1 promoter is common and occurs in advanced stage of Tunisian nasopharyngeal carcinoma.
- Authors
Fendri, Ali; Khabir, Abdelmajid; Hadri-Guiga, Boutheina; Sellami-Boudawara, Tahia; Daoud, Jamel; Frikha, Mounir; Ghorbel, Abdelmonem; Gargouri, Ali; Mokdad-Gargouri, Raja
- Abstract
Activation of the wingless-type (Wnt) signaling pathway is common in cancers. The Wnt inhibitory factor-1 (WIF-1) is a secreted antagonist that acts by binding to Wnt ligands. We examined by methylation-specific PCR (MSP), whether WIF-1 is inactivated in 68 nasopharyngeal carcinomas (NPC), and 10 normal mucosa. We showed that the WIF-1 promoter was methylated in 89.7% of tumors, whereas all normal mucosa were unmethylated. The WIF-1 methylation was associated with the tumor, node, and metastasis (TNM) (p = .003) and the age (p = .014). The Wnt-5a mRNA was higher in tumors and correlated with TNM (p = .012). The methylation of WIF-1 contributes to the activation of the Wnt pathway in NPC.
- Publication
Cancer investigation, 2010, Vol 28, Issue 9, p896
- ISSN
1532-4192
- Publication type
Journal Article
- DOI
10.3109/07357907.2010.494324