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- Title
Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
- Authors
Molokwu, Chidi N; Adeniji, Olajumoke O; Chandrasekharan, Shankar; Hamdy, Freddie C; Buttle, David J
- Abstract
Prostate cancer is a major cause of mortality, largely as a consequence of metastases and transformation to androgen-independent growth. Metalloproteinases are implicated in cancer progression. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are expressed in prostate cancer cells, with ADAMTS-1 and ADAMTS-15 being the most abundant. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene. ADAMTS-15 expression is predictive for survival in breast cancer, and the situation may be similar in prostate cancer, as androgen independence is usually due to aberrant signaling through its receptor.
- Publication
Cancer investigation, 2010, Vol 28, Issue 7, p698
- ISSN
1532-4192
- Publication type
Journal Article
- DOI
10.3109/07357907.2010.489538