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- Title
IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice.
- Authors
Janelsins, Michelle C; Roscoe, Joseph A; Berg, Michel J; Thompson, Bryan D; Gallagher, Mark J; Morrow, Gary R; Heckler, Charles E; Jean-Pierre, Pascal; Opanashuk, Lisa A; Gross, Robert A
- Abstract
Chemotherapeutic agents produce persistent difficulties in memory through an unknown mechanism. We tested the hypothesis that chemotherapeutic agents readily able to cross the blood-brain barrier (cyclophosphamide and fluorouracil), as opposed to those not known to readily cross the barrier (paclitaxel and doxorubicin), reduce neural cell proliferation following chemotherapy. We found that 5-bromo-2-deoxyuridine labeling following chemotherapy given to C57BL/6 mice revealed a similar reduction in neural cell proliferation in the dentate gyrus for all four agents. Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation.
- Publication
Cancer investigation, 2010, Vol 28, Issue 5, p544
- ISSN
1532-4192
- Publication type
Journal Article
- DOI
10.3109/07357900903405942