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- Title
The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis.
- Authors
Melnyk, M C; Shalev, I; Zhang, J; Bartczak, A; Gorczynski, R M; Selzner, N; Inman, R; Marsden, P A; Phillips, M J; Clark, D A; Levy, G A
- Abstract
Fibrin deposition is integral to the pathogenesis of collagen-induced arthritis (CIA), an experimental model of rheumatoid arthritis (RA). Membrane-associated fibrinogen-like protein 2 (mFGL2), a novel inducible prothrombinase, generates fibrin by an alternate pathway and has been reported to be involved in the pathogenesis of a number of immune-mediated diseases. We hypothesized that expression of mFGL2 in inflamed synovium contributes to the fibrin deposition and subsequent inflammation in arthritis.
- Publication
Scandinavian journal of rheumatology, 2011, Vol 40, Issue 4, p269
- ISSN
1502-7732
- Publication type
Journal Article
- DOI
10.3109/03009742.2010.536163