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- Title
Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK.
- Authors
Costello, Jill C; Rosenthal, Ann K; Kurup, Indira V; Masuda, Ikuko; Medhora, Meetha; Ryan, Lawrence M
- Abstract
Extracellular inorganic pyrophosphate (ePPi) is a key regulator of pathologic mineralization in articular cartilage. Articular chondrocytes generate ePPi by the transportation of intracellular PPi (iPPi) through transport mechanisms such as ANK or by the degradation of extracellular adenosine triphosphate (eATP) by ectoenzymes. Although numerous modulators of ePPi have been characterized, little is known about eATP elaboration in cartilage. We sought to determine (1) whether eATP is coordinately regulated with ePPi and (2) whether ANK transports ATP.
- Publication
Connective tissue research, 2011, Vol 52, Issue 2, p139
- ISSN
1607-8438
- Publication type
Journal Article
- DOI
10.3109/03008207.2010.491928