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- Title
Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H.
- Authors
Revheim, Mona-Elisabeth; Kristian, Alexandr; Malinen, Eirik; Bruland, Øyvind Sverre; Berner, Jeanne-Marie; Holm, Ruth; Joensuu, Heikki; Seierstad, Therese
- Abstract
Acquired resistance to imatinib is frequently caused by secondary KIT mutations. We have investigated the effects of imatinib in mice with human gastrointestinal stromal tumour (GIST) xenograft which harbours a primary exon 11 deletion mutation and a secondary imatinib resistance mutation D816H in exon 17. Such mutations are commonly present in imatinib-resistant GIST in humans.
- Publication
Acta oncologica (Stockholm, Sweden), 2013, Vol 52, Issue 4, p776
- ISSN
1651-226X
- Publication type
Journal Article
- DOI
10.3109/0284186X.2013.770920