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- Title
Macromolecular and dendrimer-based magnetic resonance contrast agents.
- Authors
Bumb, Ambika; Brechbiel, Martin W; Choyke, Peter
- Abstract
Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.
- Publication
Acta radiologica (Stockholm, Sweden : 1987), 2010, Vol 51, Issue 7, p751
- ISSN
1600-0455
- Publication type
Journal Article
- DOI
10.3109/02841851.2010.491091