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- Title
Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone.
- Authors
Bruce, R Douglas; Moody, David E; Fang, Wenfang B; Chodkowski, Diane; Andrews, Laurie; Friedland, Gerald H
- Abstract
Previous reports on the pharmacokinetic of tipranavir (TPV) and buprenorphine (BUP)/ naloxone found that coadministration resulted in an 80% reduction in the area under the curve AUC of the primary BUP metabolite, norBUP, without any pharmacodynamic consequences. This study was conducted to characterize how tipranivir/ritonavir effects the glucuronide metabolites of BUP and may explain the reduction in the norBUP.
- Publication
The American journal of drug and alcohol abuse, 2011, Vol 37, Issue 4, p224
- ISSN
1097-9891
- Publication type
Journal Article
- DOI
10.3109/00952990.2011.568081