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- Title
Factors influencing the sample size, exemplified by studies on gastroduodenal tolerability of drugs.
- Authors
Larsen, S; Osnes, M; Eidsaunet, W; Sandvik, L
- Abstract
The necessary number of subjects to be included in a clinical trial depends on different factors. Exemplified by clinical trials on gastroduodenal tolerability of NSAID, we show how the sample size increases when the significance level decreases, the detection level increases, or the clinically relevant difference decreases. The sample size also increases when the trial design is changed from a cross-over to a parallel-group design. It is concluded from an ethical and statistical point of view that the sample size must be calculated when planning a study.
- Publication
Scandinavian journal of gastroenterology, 1985, Vol 20, Issue 4, p395
- ISSN
0036-5521
- Publication type
Journal Article
- DOI
10.3109/00365528509089670