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- Title
Differential expression of Toll-like receptor pathway genes in chronic rhinosinusitis with or without nasal polyps.
- Authors
Zhang, Qi; Wang, Cheng-Shuo; Han, De-Min; Sy, Christopher; Huang, Qian; Sun, Yan; Fan, Er-Zhong; Li, Ying; Zhou, Bing
- Abstract
Our results indicate that chronic rhinosinusitis without nasal polyps (CRSsNP) is characterized by the down-regulation of a Toll-like receptor (TLR)-mediated signaling pathway and such a deficiency within the innate immune system may contribute to the inflammatory process of CRSsNP. In contrast, the inflammatory process found in CRS with nasal polyps (CRSwNP) is characterized by an excessively activated TLR-mediated signaling pathway, which may contribute to the formation of nasal polyps. This study suggests that the pathophysiologic mechanism of CRSsNP and CRSwNP is different.
- Publication
Acta oto-laryngologica, 2013, Vol 133, Issue 2, p165
- ISSN
1651-2251
- Publication type
Journal Article
- DOI
10.3109/00016489.2012.717713