We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Influence of TSPO genotype on 11C-PBR28 standardized uptake values.
- Authors
Yoder, Karmen K; Nho, Kwangsik; Risacher, Shannon L; Kim, Sungeun; Shen, Li; Saykin, Andrew J
- Abstract
(11)C-PBR28 binds to the high-affinity state of the translocator protein 18 kDa (TSPO). A single-nucleotide polymorphism (rs6971) within the human TSPO gene determines the affinity state of the TSPO. The rs6971 genotype determines whether individuals express the high-, low-, or mixed-affinity phenotype of TSPO. The rs6971 genotype corresponds to in vivo (11)C-PBR28 binding, as measured quantitatively by total volume of distribution. However, it is not known whether standardized uptake value (SUV) can detect differences in brain (11)C-PBR28 uptake by TSPO genotype.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 8, p1320
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.118885