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- Title
Determination of the in vivo selectivity of a new κ-opioid receptor antagonist PET tracer 11C-LY2795050 in the rhesus monkey.
- Authors
Kim, Su Jin; Zheng, Ming-Qiang; Nabulsi, Nabeel; Labaree, David; Ropchan, Jim; Najafzadeh, Soheila; Carson, Richard E; Huang, Yiyun; Morris, Evan D
- Abstract
(11)C-LY2795050 is a novel κ-selective antagonist PET tracer. The in vitro binding affinities (Ki) of LY2795050 at the κ-opioid (KOR) and μ-opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was to determine the in vivo selectivity of this new KOR antagonist tracer in the monkey.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 9, p1668
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.118877