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- Title
Determination of in vivo Bmax and Kd for 11C-GR103545, an agonist PET tracer for κ-opioid receptors: a study in nonhuman primates.
- Authors
Tomasi, Giampaolo; Nabulsi, Nabeel; Zheng, Ming-Qiang; Weinzimmer, David; Ropchan, Jim; Blumberg, Laura; Brown-Proctor, Clive; Ding, Yu-Shin; Carson, Richard E; Huang, Yiyun
- Abstract
The κ-opioid receptors (KOR) are involved in mood disorders and addictive conditions. In vivo imaging studies of this receptor in humans have not been reported because of the lack of a selective ligand. We used a recently developed selective KOR agonist tracer, (11)C-GR103545, and performed a study in rhesus monkeys to estimate the in vivo receptor concentration (Bmax) and dissociation equilibrium constant (Kd).
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 4, p600
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.112672