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- Title
Imaging changes in synaptic acetylcholine availability in living human subjects.
- Authors
Esterlis, Irina; Hannestad, Jonas O; Bois, Frederic; Sewell, R Andrew; Tyndale, Rachel F; Seibyl, John P; Picciotto, Marina R; Laruelle, Marc; Carson, Richard E; Cosgrove, Kelly P
- Abstract
In vivo estimation of β(2)-nicotinic acetylcholine receptor availability with molecular neuroimaging is complicated by competition between the endogenous neurotransmitter acetylcholine and the radioligand (123)I-3-[2(S)-2-azetidinylmethoxy]pyridine ((123)I-5-IA). We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine in humans, as suggested in nonhuman primates.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 1, p78
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.111922