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- Title
Development and evaluation of 18F-TTCO-Cys40-Exendin-4: a PET probe for imaging transplanted islets.
- Authors
Wu, Zhanhong; Liu, Shuanglong; Hassink, Matthew; Nair, Indu; Park, Ryan; Li, Lin; Todorov, Ivan; Fox, Joseph M; Li, Zibo; Shively, John E; Conti, Peter S; Kandeel, Fouad
- Abstract
Because islet transplantation has become a promising treatment option for patients with type 1 diabetes, a noninvasive imaging method is greatly needed to monitor these islets over time. Here, we developed an (18)F-labeled exendin-4 in high specific activity for islet imaging by targeting the glucagonlike peptide-1 receptor (GLP-1R).
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 2, p244
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.109694