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- Title
18F-flumazenil: a γ-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy.
- Authors
Vivash, Lucy; Gregoire, Marie-Claude; Lau, Eddie W; Ware, Robert E; Binns, David; Roselt, Peter; Bouilleret, Viviane; Myers, Damian E; Cook, Mark J; Hicks, Rodney J; O'Brien, Terence J
- Abstract
Studies report that (11)C-flumazenil (FMZ) PET more specifically localizes the epileptogenic zone in patients with medically refractory focal epilepsy than (18)F-FDG PET. However, practical aspects of (11)C use limit clinical application. We report a phase I/IIa study assessing the clinical use of (18)F-FMZ PET for the localization of the epileptogenic zone in patients with drug-resistant temporal lobe epilepsy (TLE). Receptor binding was quantified using kinetic modeling that did not require arterial sampling.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Vol 54, Issue 8, p1270
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.107359