We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF.
- Authors
Hall, Mary A; Pinkston, Kenneth L; Wilganowski, Nathaniel; Robinson, Holly; Ghosh, Pradip; Azhdarinia, Ali; Vazquez-Arreguin, Karina; Kolonin, Arseniy M; Harvey, Barrett R; Sevick-Muraca, Eva M
- Abstract
The proliferation of most carcinomas is associated with an overexpression of epithelial cell adhesion molecule (EpCAM), a 40-kDa type I transmembrane protein found on epithelial cells yet absent from other cell types. The absence of EpCAM in normal lymphatics makes it an attractive marker for studying lymph node (LN) metastases of carcinomas to improve LN staging accuracy. Herein, we developed and quantitatively compared dual-labeled monoclonal antibodies (mAbs) of varying affinities against EpCAM for both noninvasive and intraoperative detection of metastatic LNs in prostate cancer.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 9, p1427
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.106302