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- Title
Caffeine occupancy of human cerebral A1 adenosine receptors: in vivo quantification with 18F-CPFPX and PET.
- Authors
Elmenhorst, David; Meyer, Philipp T; Matusch, Andreas; Winz, Oliver H; Bauer, Andreas
- Abstract
Caffeine is the neuroactive agent in coffee and tea and is a broadly consumed stimulant. It is a nonselective antagonist of the neuromodulator adenosine and, if applied in commonly consumed doses, evokes its stimulating effects through the blockade of adenosine receptors. (18)F-8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ((18)F-CPFPX) has been established as a highly selective and affine PET ligand for the A(1) adenosine receptor (A(1)AR). The objective of the present study was to visualize and quantify the in vivo occupancy of the human cerebral A(1)AR by caffeine using (18)F-CPFPX and PET.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 11, p1723
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.105114