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- Title
Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer.
- Authors
Fowler, Amy M; Chan, Szeman Ruby; Sharp, Terry L; Fettig, Nicole M; Zhou, Dong; Dence, Carmen S; Carlson, Kathryn E; Jeyakumar, M; Katzenellenbogen, John A; Schreiber, Robert D; Welch, Michael J
- Abstract
Estrogen receptor-α (ERα) and progesterone receptor (PR) are expressed in most human breast cancers and are important predictive factors for directing therapy. Because of de novo and acquired resistance to endocrine therapy, there remains a need to identify which ERα-positive (ERα(+))/PR-positive (PR(+)) tumors are most likely to respond. The purpose of this study was to use estrogen- and progestin-based radiopharmaceuticals to image ERα and PR in mouse mammary tumors at baseline and after hormonal therapy and to determine whether changes in these imaging biomarkers can serve as an early predictive indicator of therapeutic response.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 7, p1119
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.112.103465