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- Title
In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET.
- Authors
Normandin, Marc D; Petersen, Kitt F; Ding, Yu-Shin; Lin, Shu-Fei; Naik, Sarita; Fowles, Krista; Skovronsky, Daniel M; Herold, Kevan C; McCarthy, Timothy J; Calle, Roberto A; Carson, Richard E; Treadway, Judith L; Cline, Gary W
- Abstract
The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would accelerate research on the pathophysiology of diabetes and revolutionize the preclinical development of new treatments, the clinical assessment of therapeutic efficacy, and the early diagnosis and subsequent monitoring of disease progression. The vesicular monoamine transporter type 2 (VMAT2) is coexpressed with insulin in β-cells and represents a promising target for BCM imaging.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 6, p908
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.111.100545