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- Title
Molecular imaging of very late antigen-4 (α4β1 integrin) in the premetastatic niche.
- Authors
Shokeen, Monica; Zheleznyak, Alexander; Wilson, Jessica M; Jiang, Majiong; Liu, Ruiwu; Ferdani, Riccardo; Lam, Kit S; Schwarz, Julie K; Anderson, Carolyn J
- Abstract
Despite advances in cancer treatment over the past few decades, metastatic disease remains the primary cause of morbidity and mortality. Recent reports suggest the formation of a "premetastatic niche" before the metastatic cascade, where niche is defined as the microenvironment for tumor cells to be able to engraft and proliferate at secondary sites. Bone marrow-derived (BMD) cells that express vascular endothelial growth factor receptor-1 and very late antigen-4 (VLA-4) have been shown to arrive at sites of metastasis to form a receptive environment for tumor cells. Here we describe experiments toward imaging of VLA-4-positive BMD cells using a high-affinity PET probe, (64)Cu-labeled 11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2] hexadecane (CB-TE2A)-LLP2A.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 5, p779
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.111.100073