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- Title
Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acid therapy of high-risk osteosarcoma.
- Authors
Senthamizhchelvan, Srinivasan; Hobbs, Robert F; Song, Hong; Frey, Eric C; Zhang, Zhe; Armour, Elwood; Wahl, Richard L; Loeb, David M; Sgouros, George
- Abstract
(153)Sm-ethylenediamine tetramethylene phosphonic acid ((153)Sm-EDTMP) therapy for osteosarcoma is being investigated. In this study, we analyzed the influence of (153)Sm-EDTMP administered activity (AA), osteosarcoma tumor density, mass, and the shape of the tumor on absorbed dose (AD). We also studied the biologic implication of the nonuniform tumor AD distribution using radiobiologic modeling and examined the relationship between tumor AD and response.
- Publication
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Vol 53, Issue 2, p215
- ISSN
1535-5667
- Publication type
Journal Article
- DOI
10.2967/jnumed.111.096677